Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do diuretics cause magnesium deficiency?

D L Davies1, R Fraser

  • 1Department of Medicine and Therapeutics, Western Infirmary, Glasgow.

British Journal of Clinical Pharmacology
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation.

bioRxiv : the preprint server for biology·2023
Same author

Supplementation with sodium butyrate protects against antibiotic-induced increases in ethanol consumption behavior in mice.

Alcohol (Fayetteville, N.Y.)·2022
Same author

Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol.

Neuroscience·2015
Same author

A cluster separation measure.

IEEE transactions on pattern analysis and machine intelligence·2011
Same author

The selection of critical subsets for signal, image, and scene matching.

IEEE transactions on pattern analysis and machine intelligence·2011
Same author

Plasma Renin Concentration in Human Hypertension-III: Renin in Relation to Complications of Hypertension.

British medical journal·2010
Same journal

N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

British journal of clinical pharmacology·2026
Same journal

Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

British journal of clinical pharmacology·2026
Same journal

Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

British journal of clinical pharmacology·2026
Same journal

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

British journal of clinical pharmacology·2026
Same journal

Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

British journal of clinical pharmacology·2026
Same journal

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

British journal of clinical pharmacology·2026
See all related articles

Most patients taking thiazide diuretics do not require magnesium supplements. Potassium-sparing diuretics may increase magnesium levels, but controlled trials are limited for loop diuretics and high-dose use.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Biochemistry

Background:

  • Diuretics are commonly prescribed for various medical conditions.
  • Concerns exist regarding their potential to cause magnesium deficiency.
  • Accurate assessment of magnesium status is crucial for patient management.

Purpose of the Study:

  • To evaluate the evidence linking diuretic use to magnesium deficiency.
  • To assess the need for magnesium supplementation in patients on diuretics.
  • To discuss advancements in measuring intracellular magnesium levels.

Main Methods:

  • Review of controlled trials on diuretics and magnesium levels.
  • Analysis of existing literature on thiazide, potassium-sparing, and loop diuretics.
  • Discussion of novel methods for intracellular free magnesium measurement.

Related Experiment Videos

Main Results:

  • Controlled trials do not support claims that thiazide diuretics cause magnesium deficiency at standard doses.
  • Potassium-sparing diuretics tend to increase, not decrease, magnesium levels.
  • Evidence is insufficient to recommend magnesium supplementation for most patients on conventional diuretic therapy.

Conclusions:

  • Magnesium supplementation is generally not necessary for patients on standard thiazide diuretics.
  • Further research, with improved trial design, is needed to clarify the effects of high-dose loop diuretics on magnesium balance.
  • New methods for measuring intracellular free magnesium offer more relevant insights into magnesium status.