Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does polyethylene oxide possess a low thrombogenicity?

G R Llanos1, M V Sefton

  • 1Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada.

Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methods for Microencapsulation with HEMA-MMA.

Methods in molecular medicine·2011
Same author

Fibronectin coating of collagen modules increases in vivo HUVEC survival and vessel formation in SCID mice.

Acta biomaterialia·2010
Same author

Complement inhibition reduces material-induced leukocyte activation with PEG modified polystyrene beads (Tentagel) but not polystyrene beads.

Journal of biomedical materials research. Part A·2005
Same author

Viability of hydroxyethyl methacrylate-methyl methacrylate-microencapsulated PC12 cells after omental pouch implantation within agarose gels.

Tissue engineering·2003
Same author

Material-induced tissue factor expression but not CD11b upregulation depends on the presence of platelets.

Journal of biomedical materials research. Part A·2003
Same author

Tissue engineering as a platform for controlled release of therapeutic agents: implantation of microencapsulated dopamine producing cells in the brains of rats.

Journal of controlled release : official journal of the Controlled Release Society·2001
Same journal

Polyhydroxybutyrate nanoparticles for encapsulating carvacrol: release in food simulants, antimicrobial applications and human health potential.

Journal of biomaterials science. Polymer edition·2026
Same journal

<i>In vivo</i> assessment of rosmarinic acid phytosomes for concurrent antidiabetic and antihypertensive effects.

Journal of biomaterials science. Polymer edition·2026
Same journal

Coaxially electrospun silk fibroin scaffold incorporating kartogenin via β-cyclodextrin for rotator cuff repair.

Journal of biomaterials science. Polymer edition·2026
Same journal

Rational lipid screening for the development of solid lipid nanoparticles and nanostructured lipid carriers: formulation, characterization and <i>in vitro</i> evaluation.

Journal of biomaterials science. Polymer edition·2026
Same journal

<i>In vitro</i> and <i>in vivo</i> evaluation of DNA-integrated diclofenac-HPMC hydrogel for enhanced ocular anti-inflammatory drug delivery.

Journal of biomaterials science. Polymer edition·2026
Same journal

Fabrication of bi-layered bioresorbable ureteral stent and <i>in-vitro</i> analysis for sustained therapeutics.

Journal of biomaterials science. Polymer edition·2026
See all related articles

Polyethylene oxide surfaces reduce protein and cell adhesion, but it is unclear if this is due to hydrophilicity or inherent properties. Further research is needed to confirm reduced thrombogenicity.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biomedical Engineering

Background:

  • Polyethylene oxide (PEO) exhibits 'bland' interactions with proteins and cells.
  • Efforts focus on creating PEO-rich surfaces via block copolymers and immobilization.
  • PEO-modified surfaces show reduced protein adsorption and cell adhesion compared to hydrophobic substrates.

Purpose of the Study:

  • To investigate the mechanisms behind reduced protein and cell adhesion on PEO-rich surfaces.
  • To determine if reduced adhesion is due to PEO's thermodynamic effects or increased surface hydrophilicity.
  • To assess if reduced adhesion correlates with decreased thrombogenicity.

Main Methods:

  • Surface modification techniques including block copolymers and immobilization.

Related Experiment Videos

  • Comparison of PEO-rich surfaces with unmodified hydrophobic substrates.
  • Analysis of protein adsorption and cell adhesion levels.

    • Main Results:

    • PEO-rich surfaces demonstrate significantly lower cell (including platelet) adhesion and protein adsorption.
    • The precise cause of this reduction (thermodynamic effect vs. hydrophilicity) remains ambiguous.
    • A clear link between reduced adhesion/adsorption and decreased thrombogenicity has not been established.

    Conclusions:

    • While PEO surface modification effectively reduces non-specific binding, the underlying mechanisms require further elucidation.
    • The relationship between reduced adhesion and actual thrombogenicity is not yet definitively proven.
    • Further studies are necessary to confirm the antithrombotic potential of PEO-modified biomaterials.