[The effect of high-altitude ecological and experimental stresses on the thrombocyte-vascular wall system]

Experiments in animals (rats) and examinations of the population of high-altitude shepherds were used to study the functional system "Thrombocytes-Vessel Wall" (STVW) for evaluation of the organism ecological adaptation to "pure" high-altitude stress, with and without combination with experimental-adrenergic cardionecrosogenic stress (ACNS, in rats). The adaptive increase of antiaggregation prostacyclin activity of the aorta in rats and PGI2 reaction of vessels in human population of high-altitude in mountains (2000, 3000-3500 m) were found to be a common biologist regularity. The adaptive increase of coronary reserve of the heart and vasodilatator-antiaggregation status in high-altitude shepherds correlated with an increase of antiaggregation activity of the aorta and decrease of spontaneous aggregation of the thrombocytes in rats under conditions of more prolonged adaptation to high-altitude ecological stress.