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Donor for BMT with haemoglobin H disease
J Y Peltier1, D Girault, M Debre
1Laboratoire d'Hématologie, Hôpital Necker-Enfants Malades, Paris, France.
Bone Marrow Transplantation
|July 1, 1993
Summary
Allogeneic bone marrow transplant (BMT) successfully treated juvenile chronic myelogenous leukemia (JCML) in an infant. A donor with mild HbH disease is suitable for BMT, even with complex recipient hemoglobinopathies.
Area of Science:
- Hematology
- Pediatric Oncology
- Genetics
Background:
- Juvenile chronic myelogenous leukemia (JCML) is a rare and aggressive hematologic malignancy in infants.
- Complex hemoglobinopathies are prevalent in Southeast Asia, complicating treatment decisions.
- Allogeneic bone marrow transplantation (BMT) is a potential curative option for JCML.