The GDB Human Genome Data Base: a source of integrated genetic mapping and disease data

Area of Science:

• Genomics
• Bioinformatics
• Medical Genetics

Background:

• The Human Genome Initiative generates vast amounts of data requiring integrated management.
• Existing databases often lack comprehensive integration of gene mapping and clinical information.
• A centralized, accessible repository is crucial for advancing genomic research and understanding genetic diseases.

Purpose of the Study:

• To provide an overview of the GDB (Human Genome Data Base) and OMIM (Online Mendelian Inheritance in Man) databases.
• To describe the context, development, structure, content, and utilization of these integrated resources.
• To highlight the accessibility and value of GDB and OMIM for the scientific community.

Main Methods:

• Integration of GDB (human gene mapping data) and OMIM (genetic disease and phenotype descriptions).
• Continuous updating and editing of bibliographic and full-text information.
• Development of a flexible interface for data access.
• Making databases available via SprintNet and the Internet.

Main Results:

• GDB and OMIM function as a linked international repository for Human Genome Initiative data.
• The databases integrate diverse mapping data with textual descriptions of genetic conditions.
• Information is continuously updated and accessible to researchers globally without cost.

Conclusions:

• GDB and OMIM provide a comprehensive and essential resource for human genome research.
• The integrated nature and accessibility of these databases facilitate the study of gene mapping and genetic diseases.
• These databases are vital tools supporting the ongoing Human Genome Initiative.