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Somatic ribosomal changes induced by long-term potentiation of the perforant path-hippocampal CA1 synapses
J Wenzel1, N L Desmond, W B Levy
1Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Brain Research
|August 13, 1993
Abstract:
The present study quantified ribosomes, as an ultrastructural marker of neuronal protein synthesis, following long-term potentiation (LTP) in the hippocampal CA1 region in vitro. Sixty min after LTP-inducing, high-frequency stimulation of the perforant path, the total number of ribosomes, the number of polysomes, and the number of membrane-bound ribosomes increased significantly. These increases are a postsynaptic morphological correlate consistent with enhanced protein synthesis following the induction of LTP in the perforant path-CA1 system.