Related Experiment Videos
Deletion of chromosome 13 in osteosarcoma secondary to irradiation
Y Y Ozisik1, A M Meloni, M M Zalupski
1Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Cancer Genetics and Cytogenetics
|August 1, 1993
Abstract:
The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.