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A case of transitional cell carcinoma of the bladder with a del(9)(q11q21.2)
M Bernués1, C Casadevall, R Miró
1Institut de Biologia Fonamental Vincent Villar Palasí, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Cancer Genetics and Cytogenetics
|August 1, 1993
Abstract:
Monosomy for chromosome 9, as well as loss of heterozygosity for markers on this chromosome, has been detected in a high percentage of transitional cell carcinomas (TCC) of the bladder. We report a case of a TCC of the bladder with an interstitial del(9)(q11q21.2) that could be indicative of the presence of a putative tumor-suppressor gene related to bladder tumor progression. To elucidate the role of chromosome 9 in bladder tumors, it would be interesting to study a possible loss of heterozygosity in this chromosome region.