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Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis
P Basnet1, S Kadota, S Terashima
1Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Chemical & Pharmaceutical Bulletin
|July 1, 1993
Abstract:
Ethyl acetate- and n-butanol-soluble fractions of the leaves of Morus insignis showed a significant hypoglycemic activity on streptozotocin (STZ)-induced hyperglycemic rats. From these hypoglycemic activity-showing fractions, two new compounds, mulberrofuran U (2) and moracin M-3-O-beta-D-glucopyranoside (3) were isolated, along with six known compounds [beta-sitosterol, beta-sitosterol-3-O-beta-glucopyranoside, ursolic acid, moracin M (1), kaempferol-3-O-beta-glucopyranoside and quercetin-3-O-beta-glucopyranoside] and the structures of the new compounds were determined by spectroscopic and chemical methods.