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Hemostasis variables in type I diabetic patients without demonstrable vascular complications
C el Khawand1, J Jamart, J Donckier
1Department of Endocrinology and General Internal Medicine, University Clinics of Mont-Godinne (Université Catholique de Louvain), Yvoir, Belgium.
Diabetes Care
|August 1, 1993
Summary
Type I diabetes patients show increased blood clotting (hypercoagulability), even without visible vascular issues. Poor glycemic control (HbA1c levels) worsens these hemostasis disturbances, suggesting they may precede complications.
Area of Science:
- Endocrinology
- Hematology
- Vascular Biology
Background:
- Type I diabetes is associated with microvascular and macrovascular complications.
- Hemostasis alterations may play a role in the development of these complications.
Purpose of the Study:
- To investigate hemostasis variables in type I diabetic patients without evident vascular disease.
- To correlate these hemostasis variables with glycemic control (HbA1c levels).
Main Methods:
- Fifty type I diabetic patients and 50 controls were studied.
- Patients were grouped by HbA1c levels (<8% and >8%).
- Evaluated parameters included platelet count, aggregation, specific factors (beta-thromboglobulin, PF4, fibrinogen, vWF), fibrinopeptide A, lysis time, and plasma viscosity.
Main Results:
- Diabetic patients exhibited significantly higher coagulation variables compared to controls.
- Hemostatic disturbances were more pronounced in patients with poor glycemic control (higher HbA1c).
Conclusions:
- Type I diabetes is characterized by a state of hypercoagulability.
- Poor glycemic control is linked to these hemostasis disturbances.
- These alterations may precede the onset of clinically detectable vascular complications.