Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leydig cell tumor: a case report with reference to its endocrinological features

N Masumori1, Y Kumamoto, N Itoh

  • 1Department of Urology, Sapporo Medical College, Japan.

European Urology
|January 1, 1993
PubMed
Summary

This study details an adult Leydig cell tumor case with high estradiol and low testosterone. The tumor showed a diminished response to human chorionic gonadotropin stimulation, suggesting preserved LH sensitivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of major depressive disorder in self-referred patients in a late onset hypogonadism clinic.

International journal of impotence research·2007
Same author

A stone developed within the dilated intravesical ureter following ureteroscopy.

International journal of urology : official journal of the Japanese Urological Association·2002
Same author

[Small cell carcinoma of the urinary bladder: a case report].

Hinyokika kiyo. Acta urologica Japonica·2002
Same author

[Availability of NMP22 (nuclear matrix protein 22) for the diagnosis of urothelial cancer].

Hinyokika kiyo. Acta urologica Japonica·2001
Same author

[Silicate calculi: report of two cases].

Hinyokika kiyo. Acta urologica Japonica·2000
Same author

[Clinical statistics at the urological clinic of Sanjukai Hospital--statistics on new outpatients over the last five years].

Hinyokika kiyo. Acta urologica Japonica·2000

Area of Science:

  • Reproductive Endocrinology
  • Oncology

Background:

  • Leydig cell tumors are rare testicular neoplasms.
  • Hormonal imbalances, including altered sex steroid levels, can occur in Leydig cell tumors.

Observation:

  • An adult patient presented with elevated serum estradiol (E2) and suppressed serum testosterone (T).
  • A human chorionic gonadotropin (hCG) stimulation test showed a blunted but present elevation of T and E2 pre-orchiectomy.

Findings:

  • Elevated E2 likely suppressed T through direct inhibition of steroidogenesis and negative feedback on luteinizing hormone (LH).
  • Post-orchiectomy hormone levels normalized, indicating the tumor was the source of the hormonal dysfunction.
  • The tumor's response to hCG suggests it retained some sensitivity to LH stimulation.

Related Experiment Videos

Implications:

  • This case highlights the complex hormonal milieu associated with Leydig cell tumors.
  • Understanding the tumor's specific steroidogenic pathways and hormonal feedback mechanisms is crucial for diagnosis and management.
  • Further research into Leydig cell tumor pathophysiology can inform targeted therapeutic strategies.