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Ovulation after intravenous and intramuscular human chorionic gonadotropin
R A Fischer1, S T Nakajima, M Gibson
1Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington.
Fertility and Sterility
|September 1, 1993
Summary
Ovulation timing after human chorionic gonadotropin (hCG) injection varies widely, with no significant difference between intramuscular and intravenous administration. This impacts understanding of the window for conception following fertility treatments.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatment
- Assisted Reproductive Technologies
Background:
- Ovulation induction is a key component of infertility treatment.
- Human chorionic gonadotropin (hCG) is commonly used to trigger ovulation.
- Understanding the precise timing of ovulation post-hCG is crucial for optimizing conception rates.
Purpose of the Study:
- To determine the time interval from hCG administration to follicular rupture.
- To define the endocrinologic events associated with ovulation after hCG.
- To compare the timing of ovulation and hormonal changes between intravenous (IV) and intramuscular (IM) hCG administration.
Main Methods:
- Subjects received either 10,000 IU IM or 500 IU IV hCG in separate cycles.
- Follicular development was monitored via ultrasound.
- Ovulation was confirmed by ultrasound, with hormonal levels (E2 and P) measured hourly.
Main Results:
- The mean time to ovulation was 40.4 hours after IM hCG and 38.3 hours after IV hCG.
- Ovulation occurred over a broad time range (< or = 36 to > or = 48 hours) for both administration routes.
- No significant differences were observed in the time to ovulation or the rate of change in estradiol (E2) and progesterone (P) levels between IM and IV hCG.
Conclusions:
- Ovulation timing following hCG administration is variable and not precisely predictable.
- Intravenous hCG does not offer a more specific ovulation time interval compared to intramuscular hCG.
- The hormonal milieu (E2 and P levels) changes similarly regardless of hCG administration route.