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A prospective randomized comparison of zygote intrafallopian transfer and in vitro fertilization-embryo transfer for
M R Fluker1, C G Zouves, M W Bebbington
1Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
Objective:
To evaluate the efficacy of zygote intrafallopian transfer (ZIFT) versus standard IVF-ET for the treatment of nontubal factor infertility.
Design:
A prospective randomized trial.
Participants:
Fifty-nine couples undergoing oocyte retrieval for nontubal infertility in a university hospital-based IVF-ET program.
Interventions:
A maximum of four cleaving embryos were transferred into the fallopian tube or uterine cavity 48 or 55 hours after oocyte retrieval, respectively.
Main Outcome Measures:
Rates of implantation, pregnancy, and spontaneous abortion (SAB) were compared.
Results:
Clinical pregnancies occurred after 26.5% versus 12% of retrievals and 29% versus 14.3% of transfers in IVF-ET versus ZIFT cycles, respectively. Pregnancy, implantation, and SAB rates did not differ between the groups.
Conclusions:
This prospective randomized trial failed to demonstrate any therapeutic improvement associated with the increased complexity of ZIFT as compared with standard IVF-ET.