Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A multi-marker model for detecting chromosomal segments displaying QTL activity

F Rodolphe¹, M Lefort

¹INRA, Centre de Recherches de Jouy en Josas, Laboratoire de Biométrie, France.

|August 1, 1993

Summary

This study introduces a new statistical method for quantitative trait loci (QTL) detection. It identifies genomic regions influencing traits across various progenies without needing strong genetic assumptions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantitative brainstem and spinal MRI in amyotrophic lateral sclerosis: implications for predicting noninvasive ventilation needs.

Journal of neurology·2023

Same author

Comparison of spinal magnetic resonance imaging and classical clinical factors in predicting motor capacity in amyotrophic lateral sclerosis.

Journal of neurology·2023

Same author

Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis.

BMC medical research methodology·2022

Same author

[Safety and efficacy of percutaneous nephrolithotomy in patients with neurogenic bladder].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022

Same author

Ten-year follow-up after mitoxantrone induction for early highly active relapsing-remitting multiple sclerosis: An observational study of 100 consecutive patients.

Revue neurologique·2022

Same author

[External sphincterotomy in neurological patients with detrusor sphincter dyssynergia: Short and mid-term results].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2021

Area of Science:

Genetics
Biostatistics
Quantitative genetics

Background:

Detecting quantitative trait loci (QTLs) is crucial for understanding complex traits.
Existing methods often focus on individual QTLs, limiting comprehensive genomic analysis.
A need exists for methods that assess the entire genome's contribution to quantitative traits.

Purpose of the Study:

To present a novel statistical method for detecting QTLs using a linear model.
To enable the identification of chromosomal segments associated with trait variation in different genetic crosses.
To provide a tool for QTL detection that considers the genome holistically.

Main Methods:

A statistical method based on a linear model is employed.
The method treats the genome as a whole for QTL detection.

Related Experiment Videos

It accommodates codominant genetic markers and allows for missing data under specific conditions.

Main Results:

The method detects chromosomal segments involved in quantitative trait differences between homozygous lines and their progenies.
Asymptotic properties of practical utility are developed.
It assesses involved genomic regions irrespective of the complexity of genetic determinism (number, effects, interactions).

Conclusions:

This method offers a comprehensive approach to QTL detection, analyzing the genome globally.
It is valuable for identifying genomic regions associated with quantitative traits, even with complex genetic architectures.
Complementary use with other QTL detection methods can enhance overall detection efficiency.