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11q- and constitutional X trisomy in a patient with M5b acute non-lymphocytic leukemia
C Bigazzi1, P Galieni, R Scarinci
1Cattedra e Divisione di Ematologia, Siena, Italy.
Haematologica
|May 1, 1993
Abstract:
A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achieving complete remission. Abnormalities of chromosome 11 are typical of M4 and M5 ANLL. X trisomy is one of the most common human aneuploidia; however, correlation with increased incidence of hematological neoplasia has not been described.