Related Experiment Videos
A case of angiocentric immunoproliferative lesions (angiocentric lymphoma) associated with human T-cell lymphotropic
I Shimokawa1, N Ushijima, R Moriuchi
1Department of Pathology, Nagasaki University Medical School, Japan.
Abstract:
We report a case of angiocentric immunoproliferative lesions (AILs; angiocentric lymphoma) in the subcutaneous tissue associated with human T-cell lymphotropic virus type 1 (HTLV-1). The patient showed an indolent cutaneous manifestation for 9 years until death. A skin biopsy revealed an angiocentric infiltration of atypical T lymphocytes and a marked coagulative necrosis, which are histologic hallmarks of AILs. Human T-cell lymphotropic virus type 1 antibody was detected by the indirect immunofluorescence test. The proviral integration of HTLV-1 also was confirmed in a DNA extract from paraffin sections using the polymerase chain reaction. The Epstein-Barr virus genome, which has been reported to be associated with AILs, could not be detected by polymerase chain reaction. The present case indicated that HTLV-1 also should be considered one of the pathogenetic factors of AILs.