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[Digestive carcinoids and synchronous malignant tumors]
1Service de chirurgie, CHUV, Lausanne.
Helvetica Chirurgica Acta
|June 1, 1993
Summary
Digestive carcinoid tumors are often found with other synchronous tumors, particularly colorectal adenocarcinomas. The prognosis is primarily determined by the associated malignancy, not the carcinoid itself.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Context:
- Analysis of 270 digestive carcinoid tumors diagnosed between 1971 and 1990.
- Focus on 21 cases with synchronous tumors, predominantly appendiceal, small bowel, and colorectal carcinoids.
Purpose:
- To investigate the association between digestive carcinoid tumors and other synchronous malignancies.
- To evaluate the impact of these associations on patient prognosis and survival.
- To explore potential hypotheses explaining the observed tumor co-occurrences.
Summary:
- 21 of 270 digestive carcinoid tumors were associated with other synchronous tumors, most commonly colorectal adenocarcinomas.
- Carcinoid tumors were most frequent in the appendix (33%), small bowel (38%), and colorectum (25%).
- The majority (80%) of carcinoids were incidentally discovered during the management of the co-existing malignancy.
Impact:
- Patient survival is dictated by the stage and aggressiveness of the primary associated tumor.
- Digestive carcinoid tumors generally do not alter the overall prognosis, with rare exceptions.
- Histological features of the carcinoid tumors were unremarkable, suggesting non-specific associations.