[Does fibrin glue accelerate wound healing? An autoradiography study of bone defects]

The first 96 hours of wound healing were studied in 80 drillholes in 40 rat skullpans. 40 drillholes were filled with the fibrin tissue glue Tissucol. The other 40 drillholes were only treated by compression until hemostasis was achieved. The marker 3H-Thymidine was injected intraperitoneally one hour before killing the rats. Ten rats at a time were killed after 24, 48, 72 and 96 hours. We saw a significant higher incorporation of 3H-Thymidine in the fibrin sealed holes after 48 and 72 hours. We conclude that wound healing during the first 3 days is stimulated in the presence of fibringlue.