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Binaural auditory processing in multiple sclerosis subjects

R A Levine1, J C Gardner, S M Stufflebeam

  • 1Massachusetts Eye and Ear Infirmary, Boston 02114.

Hearing Research
|June 1, 1993
PubMed
Summary
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Human auditory processing links behavioral, electrophysiological, and anatomical data in brainstem lesion patients. Interaural time discrimination is closely tied to brainstem auditory evoked potentials and stimulus spectrum.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Clinical Neuroscience

Background:

  • Relating human auditory processing to animal experimental data is crucial.
  • Focal brainstem lesions in humans provide a model to study auditory pathways.
  • Multiple Sclerosis (MS) offers a unique condition to investigate these relationships.

Purpose of the Study:

  • To examine interrelationships between behavioral, electrophysiological, and anatomical data in human subjects with focal brainstem lesions.
  • To correlate auditory performance, evoked potentials, and lesion anatomy in MS patients.
  • To develop a model for understanding human auditory processing based on animal studies.

Main Methods:

  • Studied 38 subjects with Multiple Sclerosis (MS).
  • Utilized tests for interaural time and level discrimination (just noticeable differences or jnds) with high-pass and low-pass noise bursts.

Related Experiment Videos

  • Performed brainstem auditory evoked potentials (BAEPs) and magnetic resonance (MR) imaging.

    • Main Results:

    • Abnormal interaural time discrimination (Tjnd) was more common (70%) than abnormal level jnds (11%), especially with high-pass noise.
    • High-pass Tjnd abnormalities could occur independently, but were always present with other abnormalities.
    • Lesions in the pontine auditory pathway correlated with abnormal BAEPs and Tjnds, but not always with abnormal level jnds.

    Conclusions:

    • Interaural time discrimination is closely linked to BAEPs and depends on stimulus spectrum.
    • The high-pass Tjnd is a sensitive indicator of neural desynchrony.
    • MS lesions affecting the pontine auditory pathway consistently cause abnormal BAEPs and Tjnds, validating a model linking human and animal auditory processing data.