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Related Experiment Videos

Ventilatory pattern after hypoxic stimulation during wakefulness and NREM sleep

K Gleeson1, L W Sweer

  • 1Division of Pulmonary and Critical Care Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1993
PubMed
Summary

The ventilatory after-discharge mechanism (VAD) stabilizes breathing after hyperventilation. This study found VAD causes hypopnea during sleep when hypoxia is replaced with oxygen, but not room air.

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Area of Science:

  • Physiology
  • Sleep Medicine
  • Respiratory Control

Background:

  • The ventilatory after-discharge mechanism (VAD) may stabilize ventilation (VE) post-hyperventilation.
  • VAD has not been studied in human sleep, a period common for respiratory disorders.
  • Previous studies suggest VAD during wakefulness.

Purpose of the Study:

  • To characterize the human ventilatory response after hypoxic stimuli termination during wakefulness and NREM sleep.
  • To investigate the role of hyperoxia in VAD during sleep.

Main Methods:

  • Two experiments were conducted on 14 healthy young men during wakefulness and NREM sleep.
  • Hypoxic stimulus (10-12% O2 for 45-60s) was terminated by 100% O2.
  • A second experiment used room air termination in NREM sleep.

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Main Results:

  • Hypoxia caused similar VE increases and end-tidal PCO2 decreases during wakefulness and sleep.
  • Termination of hypoxia with 100% O2 induced hypopnea in all subjects during sleep (VE decrease of 65.5%).
  • Termination with room air did not cause hypopnea during sleep.

Conclusions:

  • The ventilatory after-discharge mechanism (VAD) is present during human NREM sleep.
  • Non-physiological hyperoxia following hypoxia triggers hypopnea during sleep.
  • Room air termination of hypoxia does not elicit hypopnea, suggesting a role for oxygen levels in VAD regulation during sleep.