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Related Experiment Videos

Computed tomographic analysis of pes cavus

A E Price1, R Maisel, J C Drennan

  • 1Department of Orthopaedic Surgery, New York University Medical Center, NY 10016.

Journal of Pediatric Orthopedics
|September 1, 1993
PubMed
Summary

Peripheral neuropathies cause muscle degeneration, particularly in the intrinsic foot muscles. This study reveals a centripetal pattern of degeneration in hereditary sensory motor neuropathies.

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Area of Science:

  • Neurology
  • Radiology
  • Genetics

Background:

  • Peripheral neuropathies can lead to significant muscle degeneration.
  • Pes cavus deformity is a common clinical manifestation in certain hereditary sensory motor neuropathies (HSMN).
  • Understanding muscle involvement patterns is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the patterns of muscle degeneration in patients with peripheral neuropathies and pes cavus.
  • To correlate muscle degeneration with clinical and radiographic findings.
  • To identify specific muscle groups affected early in the disease process.

Main Methods:

  • Computed tomography (CT) scans of the feet and legs were performed on 26 patients with HSMN I, II, or III.
  • Clinical and radiographic assessments were conducted.

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  • Multiple regression/correlation analysis was used to analyze muscle degeneration patterns alongside variables like age, sex, and foot deformities.

    • Main Results:

    • Intrinsic foot muscles showed earlier and more severe degeneration than extrinsic muscles.
    • Pedal lumbricals and interossei exhibited the most consistent early degeneration.
    • A centripetal pattern of muscle degeneration was observed, with two distinct patterns (Type P and Type T) noted in leg muscle involvement based on nerve innervation.

    Conclusions:

    • Muscle degeneration in these neuropathies progresses from distal to proximal.
    • Intrinsic pedal muscles are the primary targets in early-stage disease.
    • Specific patterns of leg muscle degeneration correlate with peroneal or posterior tibial nerve involvement.