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The isolation and structural elucidation of four novel triterpene lactones, pseudolarolides A, B, C, and D, from
1Department of Chemistry of Natural Drugs, School of Pharmacy, Shanghai Medical University, People's Republic of China.
Journal of Natural Products
|July 1, 1993
Abstract:
Four novel triterpene lactones, pseudolarolides A [1], B [2], C [3], and D [4], were isolated from the seeds of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated from spectral data. Compound 2 shows potent cytotoxicity against three human cancer cell lines, KB (nasopharyngeal), A-549 (lung), and HCT-8 (colon), and against a murine leukemia cell line (P-388) with ED50 values of 0.49, 0.67, 0.73, and 0.79 micrograms/ml, respectively.