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Immunostimulant agents from Andrographis paniculata

A Puri1, R Saxena, R P Saxena

  • 1Division of Biochemistry, Central Drug Research Institute, Lucknow, India.

Journal of Natural Products
|July 1, 1993
PubMed
Summary
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Andrographis paniculata extracts and andrographolides boost immune responses in mice. The plant extract showed stronger immunostimulatory effects than purified andrographolides, suggesting other active compounds.

Area of Science:

  • Immunology
  • Pharmacology
  • Ethnobotany

Background:

  • Andrographis paniculata is a medicinal herb used in traditional medicine.
  • Its potential immunomodulatory properties warrant scientific investigation.

Purpose of the Study:

  • To investigate the effects of Andrographis paniculata extract and andrographolides on specific and non-specific immune responses in mice.

Main Methods:

  • Mice were treated with ethanol extract or purified andrographolides.
  • Immune responses were assessed by antibody production, delayed type hypersensitivity (DTH), macrophage migration index (MMI), phagocytosis, and splenic lymphocyte proliferation.

Main Results:

  • Both extract and andrographolides significantly stimulated antibody and DTH responses to sheep red blood cells (SRBC).

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  • Non-specific immune responses, including MMI, phagocytosis of E. coli, and lymphocyte proliferation, were also enhanced.
  • The ethanol extract demonstrated a more pronounced immunostimulatory effect compared to purified andrographolides.

    • Conclusions:

    • Andrographis paniculata possesses significant immunostimulatory properties.
    • Compounds other than andrographolides in the plant extract may contribute to its immune-enhancing effects.