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[Risk factors for coronary artery disease in Japanese patients with chronic renal failure]
H Hase1, R Nakamura, K Ui
13rd Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
Insights
Smoking and diabetes are independent risk factors for coronary artery disease (CAD) in Japanese patients with chronic renal failure (CRF). These findings highlight key modifiable factors for CAD prevention in this population.
Area of Science:
- Nephrology
- Cardiology
- Epidemiology
Context:
- Chronic renal failure (CRF) is associated with an increased risk of cardiovascular complications.
- Identifying specific risk factors for coronary artery disease (CAD) in CRF patients is crucial for targeted interventions.
Purpose:
- To investigate the influence of established risk factors on the incidence of CAD in Japanese patients with CRF.
- To identify independent predictors of CAD in this specific patient cohort.
Summary:
- A study of 101 Japanese CRF patients revealed CAD in 25 individuals.
- Significantly higher rates of male gender, smoking, diabetes, and hypertension were observed in patients with CAD.
- Stepwise logistic regression identified a history of smoking and the presence of diabetes as independent risk factors for CAD.
Impact:
- This research underscores the importance of smoking cessation and diabetes management in preventing CAD among Japanese patients with CRF.
- Findings can inform clinical practice guidelines and public health strategies for cardiovascular risk reduction in renal disease populations.
Abstract:
We examined the records of 101 Japanese patients with chronic renal failure (CRF) to determine the influence of established risk factors on the incidence of coronary artery disease (CAD). CAD was found in 25 patients (myocardial infarction in 18, significant coronary artery stenosis by coronary angiogram in 16). In patients with CAD, there were significantly more male (80% vs 58%, p < 0.05), more smokers (80% vs 41%, p < 0.0005), more diabetics (68% vs 32%, p < 0.005) and more hypertensives (92% vs 76%, p < 0.05). However, lipoprotein (a), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or triglycerides were not significantly different between CAD group and control group. When significant risk factors were entered into a stepwise logistic regression analysis, we found a history of smoking (p = 0.0025) and the presence of diabetes (p = 0.0141) to be independent risk factors for the presence of CAD in Japanese patients with CRF.