[Thrombocytic-vascular hemostasis at rest and under physical loading in patients with ischemic heart disease]

There was a relationship of the degree of imbalance between thromboxane and prostacyclin, prostaglandins (PG) F2 alpha and E1 in patients with coronary heart disease concurrent with stable angina pectoris. A significant increase in the levels of thromboxane and PGF2 alpha was found with relative prostacyclin and PGE1 deficiency during graded exercise at the moment of transient myocardial ischemia; the imbalance significantly increased as exercise tolerance decreased. Transient myocardial ischemia induced by transesophageal left atrial pacing revealed unidirectional changes in plasma PG, as did exercise.