Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell and tissue responses to oxidative damage

Y M Janssen1, B Van Houten, P J Borm

  • 1Department of Pathology, University of Vermont, Burlington.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.

Nature communications·2018
Same author

Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics.

European cells & materials·2018
Same author

[Trimethylaminuria: 'Help, my child smells of fish!']

Nederlands tijdschrift voor geneeskunde·2018
Same author

Ambient Particulate Matter Induces Oxidative Dna Damage in Lung Epithelial Cells.

Inhalation toxicology·2015
Same author

Chronic Inflammation and Tumor Formation in Rats After Intratracheal Instillation of High Doses of Coal Dusts, Titanium Dioxides, and Quartz.

Inhalation toxicology·2015
Same author

Non-animal Tests for Evaluating the Toxicity of Solid Xenobiotics.

Alternatives to laboratory animals : ATLA·2015

Oxidative stress triggers diverse cellular responses, including gene expression changes, antioxidant production, and alterations in cell growth. These responses can lead to adaptation, cell death, or aberrant proliferation, potentially causing diseases like cancer.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Oxidative stress significantly impacts mammalian cell gene expression.
  • Cellular responses to oxidative injury are complex and varied.
  • Understanding these responses is crucial for disease pathogenesis.

Purpose of the Study:

  • To characterize cellular responses to oxidative injury.
  • To elucidate the regulatory mechanisms of these responses.
  • To determine the outcomes of oxidative stress on cells and tissues.

Main Methods:

  • Review of identified genes induced by oxidant stresses.
  • Analysis of cellular responses including cytotoxicity, cytostasis, and proliferation.
  • Examination of signaling pathways activated by reactive oxygen species (ROS).

Related Experiment Videos

Main Results:

  • Numerous genes, including transcription factors and antioxidants like heme oxygenase, MT, and MnSOD, are induced by oxidative stress.
  • Cellular responses range from growth arrest (e.g., gadd genes) to increased proliferation (e.g., ODC, proto-oncogenes).
  • Reactive oxygen species (ROS) activate signaling pathways leading to diverse protein production.

Conclusions:

  • Cellular responses to oxidative stress can restore function, lead to adaptation, cell death, or aberrant proliferation.
  • Aberrant proliferation and cell death are linked to disease states, including cancer.
  • The balance of cellular responses determines the ultimate fate and health of the cell or tissue.