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[Hemodynamic changes in acute pancreatitis]

M Kitano1, H Yoshii, S Okusawa

  • 1Department of Surgery, Saiseikai Kanagawaken Hospital, Yokohama, Japan.

Nihon Geka Gakkai Zasshi
|August 1, 1993
PubMed
Summary
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Severe pancreatitis patients exhibit a hyperdynamic hemodynamic state with myocardial depression. Moderate pancreatitis also shows a hyperdynamic state, indicating early hemodynamic changes in patients with pancreatitis.

Area of Science:

  • Cardiology
  • Gastroenterology

Context:

  • Pancreatitis, a serious inflammatory condition, can lead to significant hemodynamic alterations.
  • Early hemodynamic assessment is crucial for understanding disease severity and progression.

Purpose:

  • To investigate and compare hemodynamic profiles in patients with severe versus moderate pancreatitis during the early stages of illness.
  • To identify specific hemodynamic markers associated with pancreatitis severity.

Summary:

  • Hemodynamic studies were conducted on patients with severe (Group A) and moderate (Group B) pancreatitis from days 1-5 post-onset.
  • Both groups displayed a hyperdynamic state (increased cardiac index, decreased systemic vascular resistance).
  • Severe pancreatitis (Group A) showed higher cardiac index, lower systemic vascular resistance, lower pulmonary vascular resistance on days 1, 3, and 4, elevated pulmonary wedge pressure, and depressed left ventricular stroke work index compared to moderate pancreatitis (Group B).

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Impact:

  • Findings suggest a hyperdynamic hemodynamic state is characteristic of early-stage moderate and severe pancreatitis.
  • Myocardial depression may be a significant finding in severe pancreatitis, warranting further investigation and clinical attention.