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Related Experiment Videos

Sequential changes on 23Na MRI after cerebral infarction

T Shimizu1, H Naritomi, T Sawada

  • 1Department of Medicine, National Cardiovascular Center, Osaka, Japan.

Neuroradiology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Sodium-23 MRI detects sodium increases in the brain more than 13 hours after a stroke, indicating cell death. This technique may help assess brain cell viability following ischemic events.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Cerebral infarcts, or strokes, involve restricted blood flow to the brain, leading to neuronal damage.
  • Assessing the extent and viability of brain tissue post-stroke is crucial for treatment and prognosis.
  • Sodium-23 (23Na) Magnetic Resonance Imaging (MRI) is a technique that can visualize sodium ion distribution in tissues.

Purpose of the Study:

  • To investigate the temporal changes in 23Na MRI signals in patients with cerebral infarcts.
  • To determine the utility of 23Na MRI in differentiating between acute and chronic stroke phases.
  • To explore the potential of 23Na MRI for assessing brain cell viability after stroke.

Main Methods:

  • Seven patients with cerebral infarcts were studied using 23Na MRI.

Related Experiment Videos

  • 23Na MRI scans were performed at various time points from the acute to the chronic phase post-stroke.
  • Signal intensity changes in the affected brain regions were analyzed over time.

    • Main Results:

    • No significant 23Na MRI signal increase was observed in the first 13 hours post-stroke.
    • A definite signal increase was detected after 13 hours, peaking between 45-82 hours.
    • Signal intensity gradually decreased in subacute and chronic phases, potentially due to reduced cerebral edema.

    Conclusions:

    • 23Na MRI is insensitive to early ischemic changes in the acute stroke phase.
    • The observed sodium signal increase after 13 hours is likely due to the increased visibility of intracellular sodium in dead or dying cells.
    • 23Na MRI may serve as a valuable tool for evaluating brain cell viability in the context of ischemic stroke.