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Clinical experience with hyperthermia in conjunction with radiation therapy
H Shidnia1, N Hornback, G Ford
1Indiana University Medical Center, Indianapolis 46202-5289.
Oncology
|September 1, 1993
Summary
Hyperthermia treatment, combined with conventional therapies, showed a 93% response rate in patients with advanced cancers. Achieving temperatures of at least 40°C for 40 minutes maximized treatment effectiveness.
Area of Science:
- Oncology
- Medical Physics
Background:
- Hyperthermia is an established cancer treatment modality.
- Patients in this study had previously failed conventional therapies, including radiation, chemotherapy, and surgery.
Purpose of the Study:
- To evaluate the efficacy of hyperthermia in patients with advanced cancers.
- To determine the relationship between achieved temperature, duration, and treatment response.
Main Methods:
- Retrospective review of 421 hyperthermia treatment sessions in 73 patients.
- Analysis of complete, partial, and no response based on tumor size reduction and sustained response.
- Correlation of treatment outcomes with attained temperatures and application duration.
Main Results:
- An overall response rate of 93% was observed (45% complete response, 48% partial response).
- 7% of patients showed no response to hyperthermia treatment.
- Optimal response was associated with temperatures of at least 40°C maintained for 40 minutes.
Conclusions:
- Hyperthermia is an effective treatment for advanced cancers, particularly when conventional therapies have failed.
- Treatment efficacy is directly correlated with achieved temperature and duration.
- Specific temperature and time parameters (≥40°C for 40 minutes) yield the highest response rates.