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Zero-order drug release from hydrocolloid matrices

J E Möckel1, B C Lippold

  • 1Galenical Development, Boehringer Mannheim GmbH, Germany.

Pharmaceutical Research
|July 1, 1993
PubMed
Summary

Drug release from polymer matrices depends on polymer dissolution rate. Factors like viscosity and hydrodynamics influence release, while swelling and glass transition temperature have minimal impact on low-viscosity matrices.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Drug delivery systems often utilize polymer matrices for controlled release.
  • Understanding factors influencing drug release kinetics is crucial for optimizing dosage forms.

Purpose of the Study:

  • To investigate the influence of polymer properties and experimental conditions on drug release from compressed matrices.
  • To elucidate the mechanisms controlling drug release, differentiating between polymer dissolution and diffusion.

Main Methods:

  • Fabrication of drug-loaded polymer matrices via direct compression using methylhydroxypropyl cellulose (MHPC) or polyvinylalcohol (PVAI).
  • Systematic investigation of polymer viscosity, glass transition temperature, swelling, drug concentration, solubility, and hydrodynamics on drug release profiles.
  • Analysis of drug release kinetics under varying experimental conditions.

Main Results:

  • For low-viscosity hydrocolloids, drug release is primarily controlled by polymer dissolution rate; faster dissolution leads to higher release rates.
  • Swelling, water penetration, and relaxation dynamics do not control drug release duration or kinetics.
  • Glass transition temperature does not significantly affect drug release from these hydrocolloids.
  • Increased hydrodynamic stress accelerates polymer dissolution and thus drug release.
  • For high-viscosity hydrocolloids, drug release from the swollen gel follows Higuchi-type diffusion kinetics.

Conclusions:

  • Polymer dissolution is the key mechanism controlling drug release in low-viscosity matrices, influenced by factors like hydrodynamics.
  • Diffusion becomes the rate-limiting step for drug release in high-viscosity matrices.
  • The study clarifies the distinct release mechanisms based on polymer viscosity and experimental conditions.

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