Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arginine vasopressin secretion in thyroidectomized sheep

W R Skowsky, D A Fisher

    Endocrinology
    |April 1, 1977
    PubMed
    Summary

    Hypothyroid sheep exhibit increased vasopressin secretion and altered distribution, impacting serum osmolality. These findings suggest a link between myxedema and augmented vasopressin levels in sheep.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of a paw paw herbal shampoo for the removal of head lice.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2003
    Same author

    An audit of the use of granulocyte colony-stimulating factor in septic shock.

    Internal medicine journal·2002
    Same author

    Neonatal thyroid enlargement associated with propylthiouracil therapy of Graves' disease during pregnancy: a problem revisited.

    The Journal of pediatrics·2001
    Same author

    The state and future of Mars polar science and exploration.

    Icarus·2001
    Same author

    3,3'-Diiodothyronine sulfate excretion in maternal urine reflects fetal thyroid function in sheep.

    Pediatric research·2001
    Same author

    Court procedures for handling intoxicated drivers.

    Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism·2001

    Area of Science:

    • Endocrinology
    • Sheep Physiology

    Background:

    • Thyroid hormones play a crucial role in regulating various physiological processes.
    • Myxedema, a condition of severe hypothyroidism, can lead to significant metabolic and hormonal changes.

    Purpose of the Study:

    • To investigate the impact of experimentally induced myxedema on vasopressin dynamics in sheep.
    • To compare vasopressin levels and kinetics between hypothyroid and euthyroid sheep.

    Main Methods:

    • Thyroidectomy was performed on ewes to induce myxedema, with euthyroid sheep serving as controls.
    • Radioimmunoassay was used to measure serum vasopressin concentrations.
    • Pharmacokinetic parameters including volume of distribution, half-life, and production rates were determined using [125I]-iodovasopressin.

    Main Results:

    • Hypothyroid sheep showed significantly higher mean serum vasopressin concentrations (5.1 muU/ml vs. 1.2 muU/ml) and blood production rates (2.84 mU/kg/h vs. 0.23 mU/kg/h) compared to controls.
    • The volume of distribution for vasopressin was larger in hypothyroid sheep (8.15 L vs. 5.90 L), with a shorter half-life (9.5 min vs. 19.3 min).
    • Lowered serum osmolality was observed in hypothyroid sheep (272 mosmol/kg vs. 301 mosmol/kg), suggesting increased renal and organ effectiveness of vasopressin.

    Conclusions:

    • Myxedematous state in sheep is associated with augmented vasopressin secretion.
    • Altered vasopressin kinetics and lower serum osmolality indicate a complex endocrine response to hypothyroidism.

    Related Experiment Videos