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Multicystic peritoneal mesothelioma in a Fischer-344 rat
Abstract:
A spontaneous multicystic peritoneal mesothelioma was detected in a 108-wk-old male Fischer-344/DuCrj rat. Grossly, a tumor containing numerous, semi-transparent, variously sized, thin-walled cysts was found on the splenic serosal surface. Microscopically, each cyst was surrounded by variable amounts of loose connective tissue. The luminal and free surfaces of the cysts were covered by a single layer of flattened or cuboidal mesothelial cells. No metastases were detected in any of the other organs. Diagnosis was supported by immunohistochemistry and ultrastructural features.
Insights
A rare multicystic peritoneal mesothelioma spontaneously developed in a Fischer-344 rat. This splenic tumor featured numerous thin-walled cysts lined by mesothelial cells, with no signs of metastasis.
Area of Science:
- Veterinary Pathology
- Oncology
- Mesothelioma Research
Background:
- Mesotheliomas are rare neoplasms arising from mesothelial cells.
- Spontaneous tumors in laboratory rats provide valuable models for human disease.
- Multicystic peritoneal mesothelioma is an uncommon subtype.
Purpose of the Study:
- To report a case of spontaneous multicystic peritoneal mesothelioma in a Fischer-344 rat.
- To characterize the gross, microscopic, and diagnostic features of this tumor.
- To contribute to the understanding of rare neoplasms in rodent models.
Main Methods:
- Gross examination of the tumor.
- Histopathological analysis of cyst structure and cellular lining.
- Immunohistochemistry to confirm cell type.
- Ultrastructural examination for detailed cellular features.
Main Results:
- A multicystic tumor was identified on the splenic serosal surface.
- Cysts were lined by flattened or cuboidal mesothelial cells.
- Tumor showed no evidence of metastasis to other organs.
- Immunohistochemistry and ultrastructural analysis supported the diagnosis.
Conclusions:
- The case represents a spontaneous multicystic peritoneal mesothelioma in a rat.
- The tumor exhibited characteristic mesothelial cell morphology.
- This finding highlights the importance of recognizing rare neoplasms in research animals.