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A clotting defect in an Arab colt foal

M Hinton, D R Jones, I M Lewis

    Equine Veterinary Journal
    |January 1, 1977
    PubMed

    Insights

    A rare multiple clotting defect was found in a young foal due to deficiencies in blood clotting Factors VIII, IX, and XI. Genetic testing revealed no clotting factor abnormalities in the foal

    Area of Science:

    • Veterinary Hematology
    • Equine Genetics
    • Coagulation Disorders

    Background:

    • Coagulation defects can cause severe bleeding in foals.
    • Genetic factors are often implicated in inherited bleeding disorders.

    Purpose of the Study:

    • To describe a case of multiple clotting factor deficiency in an equine foal.
    • To investigate the genetic basis of the clotting defect.

    Main Methods:

    • Coagulation factor assays were performed on the affected foal.
    • Family members (sire, dam, half-siblings) were tested for clotting factor abnormalities.

    Main Results:

    • The foal exhibited deficiencies in Factors VIII, IX, and XI.
    • No clotting factor deficiencies were identified in the foal's parents or siblings.

    Conclusions:

    • This case highlights a potential inherited multiple clotting factor deficiency in Arab foals.
    • Further research is needed to identify the specific genetic mutation responsible.

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