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On the evolution of RNA editing

P S Covello¹, M W Gray

¹Canadian Institute for Advanced Research, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia.

Trends in Genetics : TIG

|August 1, 1993

Summary

RNA editing alters RNA sequences, posing an evolutionary puzzle without clear selective advantage. A proposed model suggests co-evolution of editing sites and activity, influenced by genetic drift, explains its development.

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Area of Science:

Molecular Biology
Evolutionary Biology
Genetics

Background:

RNA editing involves modifications to RNA sequences post-transcription, differing from the DNA template.
The evolutionary origins of RNA editing are unclear, as it lacks obvious selective benefits, similar to RNA splicing.

Purpose of the Study:

To propose a model explaining the evolutionary development of RNA editing.
To investigate the co-evolutionary relationship between RNA editing sites and editing activity.
To explore the role of genetic drift in the evolution of RNA editing.

Main Methods:

Theoretical modeling approach.
Analysis of existing data on RNA editing processes.
Discussion of implications for known RNA editing forms.

Main Results:

A three-step model for RNA editing evolution is presented.
The model emphasizes the co-evolution of editing activity and specific editing sites.
Genetic drift is identified as a significant factor in this evolutionary process.

Conclusions:

The proposed model provides a framework for understanding the evolution of RNA editing.
Co-evolution and genetic drift offer a plausible explanation for the emergence of RNA editing.
This model has implications for understanding the diversity of RNA editing mechanisms observed in nature.

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