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T cell tolerance and antigen presenting cell function in the thymus

D J Izon1, J D Nieland, L A Jones

  • 1Division of Immunology, Netherlands Cancer Institute, Amsterdam.

Advances in Experimental Medicine and Biology
|January 1, 1993
PubMed
Summary
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B7 molecule expression is widespread on human immune cells, particularly dendritic cells (DC), influencing costimulatory signals. Further research will explore its role in clonal deletion processes.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The B7 molecule plays a crucial role in immune cell costimulation.
  • Previous understanding of B7 expression patterns on human leukocytes was limited.

Purpose of the Study:

  • To comprehensively map the expression of the B7 molecule on various human leukocyte populations.
  • To investigate the functional implications of B7 expression patterns in immune responses.

Main Methods:

  • Utilized anti-human B7 reagents for extensive analysis.
  • Examined B7 expression on splenic and thymic dendritic cells (DC), macrophages, B cells (activated and resting), and transformed epithelial cell lines.
  • Assessed T cell expression.

Main Results:

  • B7 expression is extensive on human leukocytes: extremely high on splenic and thymic DC, moderate on macrophages and activated B cells, and low on resting B cells.

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  • B7 was undetectable on transformed thymic epithelial cells and T cells.
  • Expression on epithelial cells in situ requires further investigation.

    • Conclusions:

    • The observed B7 expression pattern correlates with the hierarchy of costimulatory signal activity, with DC being highly effective.
    • Epithelial cells and other non-hemopoietic cells do not appear to express B7.
    • Future studies will focus on B7's involvement in clonal deletion, a process involving self-antigen presentation by DC and B cells.