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Tricyclic dose requirements across pregnancy
K L Wisner1, J M Perel, S B Wheeler
1Pregnancy and Infant/Parent Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.
The American Journal of Psychiatry
|October 1, 1993
Summary
Pregnant women may need higher doses of tricyclic antidepressants. During the third trimester, the required dosage increased by 1.6 times compared to non-pregnant levels to maintain therapeutic effects.
Area of Science:
- Pharmacology
- Obstetrics
- Psychiatry
Background:
- Tricyclic antidepressants (TCAs) are commonly used to manage various psychiatric conditions.
- Understanding medication requirements during pregnancy is crucial for maternal and fetal well-being.
Purpose of the Study:
- To investigate changes in tricyclic antidepressant (TCA) dosage requirements during pregnancy.
- To determine if TCA doses need adjustment in the second half of gestation.
Main Methods:
- A series of eight pregnant women undergoing TCA treatment were monitored.
- Serum levels and required doses for symptom remission were assessed throughout pregnancy.
Main Results:
- Tricyclic antidepressant (TCA) doses needed for symptom remission and adequate serum levels increased in the latter half of pregnancy.
- During the third trimester, the mean TCA dose was 1.6 times higher than that required during non-pregnant states.
Conclusions:
- Pregnant women may require significantly higher tricyclic antidepressant (TCA) doses, particularly in the third trimester.
- Dosage adjustments are essential to ensure therapeutic efficacy and adequate serum concentrations of TCAs during pregnancy.