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Related Experiment Videos

Aging and the Meynert cells in rhesus monkey primary visual cortex

A Peters1, C Sethares

  • 1Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118.

The Anatomical Record
|August 1, 1993
PubMed
Summary

Aging does not significantly impact Meynert cells in rhesus monkey brains. Cell numbers and morphology remain stable, with minimal accumulation of lipofuscin in these visual cortex neurons.

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Area of Science:

  • Neuroscience
  • Aging Research
  • Primate Visual System

Background:

  • Meynert cells are large neurons in layers V and VI of the cerebral cortex.
  • Understanding neuronal aging is crucial for brain health research.

Purpose of the Study:

  • To investigate the effects of aging on Meynert cells in the rhesus monkey primary visual cortex.
  • To assess changes in Meynert cell frequency, size, and cytology with age.

Main Methods:

  • Comparative analysis of Meynert cells from young, middle-aged, and old rhesus monkeys.
  • Quantification of cell density, measurement of cell body size, and examination of lipofuscin accumulation.

Main Results:

  • Meynert cell density remained consistent across age groups (20.8 cells/mm² in young vs. 22.3 cells/mm² in old monkeys).

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  • Cell body size of Meynert cells did not decrease with age.
  • Lipofuscin accumulation in Meynert cell bodies was minimal in aged monkeys.

    • Conclusions:

    • There is no significant loss of Meynert cells in the rhesus monkey with advancing age.
    • Aging has a limited impact on the morphology of Meynert cell bodies in this species.