Related Experiment Video
Updated: Aug 20, 2026
08:10
The 6-hydroxydopamine Rat Model of Parkinson's Disease
Published on: October 27, 2021
Decreased anticonvulsant activity of carbamazepine in 6-hydroxydopamine-treated rats
European Journal of Pharmacology
|February 7, 1977
Abstract:
An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of catecholamines in the forebrain, significantly lowered the electroconvulsive threshold in rats. The anticonvulsant effect of carbamazepine was also significantly reduced in the animals treated with 6-hydroxydopamine. The results are consistent with the hypothesis that brain catecholamines may play an important role in seizure susceptibility as well as in the anticonvulsant activity of carbamazepine in rats.
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