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[Acquired cerebral toxoplasmosis in an non-immunosuppressed child]
I Desguerre1, J M Pedespan, R Buissonnière
1Service de Neuropédiatrie, Hôpital Saint-Vincent-de-Paul, Paris.
Insights
This case study highlights acquired toxoplasmosis in an immunocompetent child presenting with severe neurological and cardiac symptoms. Persistent high antibody titers confirmed active disease despite treatment.
Area of Science:
- Medical Parasitology
- Immunology
- Pediatric Neurology
Background:
- Postnatally acquired toxoplasmosis is often asymptomatic.
- Severe manifestations like encephalitis, pneumonia, and myocarditis necessitate evaluation for immune deficiencies.
Background:
Postnatally acquired toxoplasmosis is relatively common as an unapparent infection. When there are severe clinical manifestations such as encephalitis, pneumonia and myocarditis, the patient should be checked for immunocompetence deficiencies.
Case Report:
A two-year old girl living in French Guyana suffered from acute respiratory distress due to interstitial pneumonia plus pericarditis that was treated by closed pericardial aspiration. Palsies of four limbs and chorioretinitis gradually appeared. The CSF protein content was elevated, 1 g/l, but the number of cells was normal. Serologic tests indicated a recent toxoplasma infection; she was given sulfadoxine, pyrimethamine and spiramycin. Her neurologic condition and the persistent antibodies, indicating active disease, led to her transfer to our Department 3 months after the onset of the disease. The CSF contained 47 cells/mm3 and 0.8 g/l proteins. Measurement of both IgM and IgG classes of toxoplasma antibodies showed persistent high titers in the blood and CSF. The CT scan showed numerous calcifications in the brain and hypodense areas in the frontal and parietal lobes. The MRI showed extensive changes. The severity of the disease in this girl led us to study her immune system. It was normal. The girl was given 6-week treatments with pyrimethamine-sulfadiazine for 2 years. This treatment stabilized the disease, but her titers of toxoplasma antibodies remained high.
Conclusion:
The initial clinical presentation of the disease in this patient and persistent high titers of toxoplasma antibodies, especially of the IgM class, argue against the possibility of congenital toxoplasmosis and favor the diagnosis of acquired disease in a patient who has no immune deficiency.