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Epstein-Barr virus and CD30+ malignant lymphomas

H Herbst1, H Stein, G Niedobitek

  • 1Institute of Pathology, Klinikum Steglitz, Free University Berlin, Germany.

Critical Reviews in Oncogenesis
|January 1, 1993
PubMed
Summary

Epstein-Barr virus (EBV) may contribute to Hodgkin's disease and CD30+ anaplastic large cell lymphoma. The virus appears to activate immature lymphoid cells, influencing the development of these cancers.

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Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Hodgkin's disease and CD30+ anaplastic large cell lymphoma are malignancies of activated lymphoid cells.
  • These cancers often originate from immature lymphoid cells with specific genetic profiles.

Purpose of the Study:

  • To investigate the potential role of Epstein-Barr virus (EBV) in the development of Hodgkin's disease and CD30+ anaplastic large cell lymphoma.
  • To explore how EBV infection might contribute to the malignant transformation of lymphoid cells.

Main Methods:

  • Phenotypic, genotypic, and karyotypic analyses were employed.
  • Detection of Epstein-Barr virus (EBV) genomes and gene products, including latent membrane protein (LMP).

Main Results:

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  • EBV genomes were detected in approximately 50% of cases studied.
  • EBV gene products, specifically LMP, were found in about 20% of cases.
  • Evidence suggests EBV may impose an activated phenotype on immature lymphoid cells.

Conclusions:

  • Epstein-Barr virus (EBV) is implicated in the pathoetiology of a significant proportion of CD30+ malignancies.
  • EBV may play a role in transforming immature lymphoid cells into malignant cells.
  • Findings support EBV as a contributing factor in specific lymphoid cancers.