Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental carcinomatous plexopathy

F Vega1, L Davila, J Y Delattre

  • 1Service de Neurologie, Hôpital de la Salpétrière, Université Paris VI, France.

Journal of Neurology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of an Allergy Study Including Rapid Provocation Tests to Identify a Safe Alternative Contrast Agent and Phenotyping of Patients With a History of Hypersensitivity to Iodinated Contrast Media.

Journal of investigational allergology & clinical immunology·2025
Same author

Contrast-associated risks of iodine-based contrast media administration in breast imaging: Tips and overview of existing evidence - A narrative review.

European journal of radiology·2025
Same author

Egg Oral Immunotherapy With Dupilumab Premedication in an Adult Patient.

Journal of investigational allergology & clinical immunology·2025
Same author

ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions.

Journal of investigational allergology & clinical immunology·2024
Same author

Adverse reactions to radiological contrast media: Prevention and treatment.

Radiologia·2024
Same author

A Reply to "Spanish Society of Allergology and Clinical Immunology (SEAIC) Vision of Drug Provocation Tests".

Journal of investigational allergology & clinical immunology·2022
Same journal

Movement disorders in GLUT1 deficiency syndrome: a systematic review of the literature.

Journal of neurology·2026
Same journal

Detailed clinical characteristics of musical hallucinations in 81 patients.

Journal of neurology·2026
Same journal

The dual role of mTOR in multiple sclerosis pathophysiology: a systematic review.

Journal of neurology·2026
Same journal

Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.

Journal of neurology·2026
Same journal

Spontaneous intracranial hypotension due to pelvic cerebrospinal fluid leak.

Journal of neurology·2026
Same journal

Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.

Journal of neurology·2026
See all related articles

Experimental thyroid carcinoma in rats revealed that tumors surrounding the brachial plexus cause nerve damage, including demyelination and axonal degeneration, leading to limb weakness. Regeneration was impaired by direct tumor invasion.

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Carcinomatous plexopathy, a complication of cancer, affects nerve function.
  • Understanding the pathophysiology of nerve damage in carcinomatous plexopathy is crucial for patient care.

Purpose of the Study:

  • To investigate the pathological changes in the brachial plexus induced by experimental thyroid carcinoma.
  • To elucidate the mechanisms of nerve damage and potential for regeneration in carcinomatous plexopathy.

Main Methods:

  • Induction of thyroid carcinoma in the brachial plexus region of 30 Fisher rats.
  • Morphological analysis including light and electron microscopy and teased fiber preparations.
  • Comparison between implanted and control brachial plexuses.

Related Experiment Videos

Main Results:

  • Tumor growth consistently surrounded the brachial plexus within 2 months.
  • Microscopic abnormalities, including endoneurial edema and demyelination, were observed in 41% of implanted rats.
  • Segmental demyelination and axonal degeneration were common, with regeneration noted in some cases, but impaired by intrafascicular invasion.

Conclusions:

  • Experimental thyroid carcinoma causes brachial plexopathy through compression and invasion, leading to demyelination and axonal degeneration.
  • While some regeneration is possible, direct tumor invasion into nerve fascicles hinders recovery.
  • This model provides insights into the mechanisms of carcinomatous plexopathy and its impact on nerve integrity.