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Related Experiment Videos

Organophosphate polyneuropathy in chicks

M Peraica1, E Capodicasa, A Moretto

  • 1Università delgi Studi di Padova, Istituto di Medicina del Lavoro, Italy.

Biochemical Pharmacology
|January 7, 1993
PubMed
Summary

Young chicks show resistance to organophosphate-induced delayed neuropathy (OPIDP), but can develop the condition with specific organophosphorus esters (OPs). Promotion with alpha-tolyl sulphonyl fluoride (PMSF) reveals age-dependent changes in OPIDP susceptibility and potential alternative targets beyond Neuropathy Target Esterase (NTE).

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Area of Science:

  • Neurotoxicology
  • Biochemistry
  • Animal Science

Background:

  • Young animals typically exhibit resistance to organophosphate-induced delayed neuropathy (OPIDP).
  • Biochemical changes in Neuropathy Target Esterase (NTE) in young animals resemble those in sensitive adult hens.
  • The mechanisms underlying age-related differences in OPIDP susceptibility remain incompletely understood.

Purpose of the Study:

  • To investigate the susceptibility of young chicks to neuropathic organophosphorus esters (OPs).
  • To examine the effect of alpha-tolyl sulphonyl fluoride (PMSF) in promoting OPIDP in chicks.
  • To determine the age-dependent changes in OPIDP development and the role of NTE inhibition.

Main Methods:

  • Administration of neuropathic OPs (DBDCVP, DFP) to 40-day-old chicks to assess ataxia induction.

Related Experiment Videos

  • Co-administration of PMSF with OPs to evaluate promotion of OPIDP.
  • Measurement of NTE inhibition levels and assessment of clinical signs and recovery patterns.

    • Main Results:

    • Ataxia was induced in 40-day-old chicks by specific OPs, presenting with spasticity and rapid recovery.
    • PMSF promoted OPIDP in chicks, with varying efficacy depending on the OP dose and timing.
    • Chicks' resistance to OPIDP decreased with age (by 60 days), and PMSF protection diminished.
    • The threshold for NTE inhibition for OPIDP development was high (95-97%), but lower (approx. 90%) when promotion occurred.

    Conclusions:

    • Chicks' resistance to OPIDP may stem from less effective NTE phosphorylation or more efficient repair mechanisms, or both.
    • PMSF promotion of OPIDP in chicks suggests a potential target other than NTE.
    • Age significantly influences susceptibility to OPIDP and the effectiveness of promoting agents.