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Related Experiment Videos

Early handling influences on behavioral and physiological responses during active avoidance

J Weinberg, S Levine

    Developmental Psychobiology
    |March 1, 1977
    PubMed
    Summary

    Early handling in rats did not change active avoidance learning performance. However, handling modulated corticosterone responses, particularly in females and during higher shock intensities in males.

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    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Animal Behavior

    Background:

    • Early life experiences, such as handling, can significantly impact an organism's development and stress responses.
    • Understanding these effects is crucial for comprehending the interplay between environment and physiology.

    Purpose of the Study:

    • To investigate the influence of early handling on behavioral and physiological reactions in rats during active avoidance learning.
    • To examine how different shock intensities affect these responses in handled versus nonhandled rats.

    Main Methods:

    • Rats (males and females) were divided into handled and nonhandled groups.
    • A 2-way shuttlebox task was employed with unconditioned stimuli of 0.5 mA or 0.8 mA.
    • Behavioral measures (response latency, defecation) and plasma corticosterone levels were recorded.

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    Main Results:

    • Higher shock intensity (0.8 mA) led to increased corticosterone, shorter response latency, and more defecation.
    • Early handling did not affect task performance but altered corticosterone response patterns.
    • Handled females exhibited lower corticosterone elevation than nonhandled females.
    • Males showed a corticosterone decrease with lower shock (0.5 mA), a pattern only observed in handled males at higher shock (0.8 mA).

    Conclusions:

    • Early handling modulates the physiological stress response (corticosterone) during active avoidance learning in rats, without impacting learning performance itself.
    • Sex differences exist in the corticosterone response to stress and handling.
    • The intensity of the stressor plays a significant role in the observed behavioral and physiological outcomes.