Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cervical (Pap) smear. New directions

L G Koss1

  • 1Department of Pathology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, New York 10467.

Cancer
|February 15, 1993
PubMed
Summary

Cervical smear screening has a significant false-negative rate for precancerous cervical lesions. Further studies are needed to determine the total error rate and improve detection accuracy for uterine cervical cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated image analysis in the diagnosis of bladder cancer.

Applied optics·2010
Same author

Harry m. Zimmerman, m.d. (1901-1995).

The American journal of pathology·2009
Same author

The mystery of chromosomal translocations in cancer.

Cytogenetic and genome research·2007
Same author

Atypical endometrial hyperplasia shares genomic abnormalities with endometrioid carcinoma by comparative genomic hybridization.

Human pathology·2001
Same author

Benign and malignant mesothelial proliferations.

The American journal of surgical pathology·2001
Same author

Evolution in cervical pathology and cytology: a historical perspective.

European journal of gynaecological oncology·2001

Area of Science:

  • Gynecology
  • Pathology
  • Oncology

Background:

  • The introduction of cervical smears revolutionized the detection of precancerous changes in the uterine cervix.
  • Understanding the historical context and evolution of cervical cancer screening is crucial for evaluating current methods.

Observation:

  • A recent laboratory analysis revealed a primary screening false-negative error rate of approximately 5% for precancerous lesions and cervical cancer.
  • Rescreening a quarter of cervical smears identified a notable percentage of missed diagnoses, indicating potential underestimation of the true error rate.

Findings:

  • The total false-negative screening error rate for cervical smears is significantly higher than initially observed and requires further investigation.
  • Identified reasons for false-negative errors include limitations in the primary screening process.

Implications:

  • Proposed remedies like widespread human papillomavirus (HPV) screening are deemed currently unacceptable due to high prevalence in asymptomatic individuals and unknown biological links to cancer.
  • Developing advanced quality control tools, such as interactive machines combining image analysis and neural networks, shows promise for enhancing screening accuracy and reducing errors.

Related Experiment Videos