Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ligand/receptor binding for 2,3,7,8-TCDD: implications for risk assessment

C Portier1, A Tritscher, M Kohn

  • 1National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
|January 1, 1993
PubMed
Summary

Dioxin exposure may not have a safe threshold. Research suggests dioxin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The origins of patchy aurora at Jupiter.

Nature communications·2026
Same author

Interstellar Mapping And Acceleration Probe: The NASA IMAP Mission.

Space science reviews·2025
Same author

Evidence of Magnetic Reconnection in Ganymede's Wake Region From Juno.

Journal of geophysical research. Space physics·2024
Same author

Virtual assessment of coronal balance prior to bone resection with the MAKO robotic-assisted system accurately predicts final balance in TKA.

Journal of robotic surgery·2023
Same author

Juno's Close Encounter With Ganymede-An Overview.

Geophysical research letters·2023
Same author

Juno Plasma Wave Observations at Ganymede.

Geophysical research letters·2023

Area of Science:

  • Toxicology and Pharmacology
  • Environmental Health
  • Biochemistry

Background:

  • Controversy exists regarding safe dioxin exposure levels.
  • Dioxin's toxic effects are hypothesized to be receptor-mediated, suggesting a potential safe threshold.
  • Established dioxin effects include altered protein levels in rodent livers.

Purpose of the Study:

  • To investigate the effects of dioxin on protein levels in rodent livers.
  • To determine if a safe threshold exists for dioxin exposure.
  • To model dioxin's impact on cytochrome P450-1A1/1A2 and epidermal growth factor receptor binding.

Main Methods:

  • Utilized an initiation-promotion protocol in female Sprague-Dawley rats.
  • Administered diethylnitrosamine followed by 2,3,7,8-TCDD (dioxin) doses.

Related Experiment Videos

  • Fitted steady-state pharmacodynamic models using Hill and Michaelis-Menten kinetics.

    • Main Results:

    • All models studied, including those allowing for a threshold, showed no safe threshold for dioxin's effects.
    • The best-fitting model indicated a proportional response to dioxin, even at low concentrations.
    • Results are consistent with receptor-mediated responses being proportional to receptor occupancy.

    Conclusions:

    • The study found no evidence of a safe threshold for dioxin's effects on specific liver proteins.
    • Dioxin's modulation of these proteins appears to be a proportional response, even at low doses.
    • Findings support the hypothesis that some receptor-mediated effects lack a low-dose threshold.