[Treatment of multiple organ failure]

Since numerous pathogenic factors are known to be involved in the development of disseminated intravascular coagulation (DIC) and multiple organ failure (MOF) in sepsis, the successful management of these clinical states is difficult. To investigate the mechanisms further, we developed experimental sepsis models associated with DIC and MOF, or endotoxin induced renal insufficiency model unaffected by prerenal factors. The hypercoagulable state leading to DIC is considered to be a prerequisite for MOF and inactivation of Xa or suppression of platelet activation is an important step to prevent the occurrence of DIC and MOF.