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[The role of autocrine motility factor receptor in metastasis]
1Dept. of Orthopedic Surgery, Gunma University School of Medicine.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 1, 1993
Abstract:
Locomotion of tumor cells and its regulation are thought to be crucial for metastasis. Autocrine motility factor (AMF) is a cytokine which stimulates in vitro motility and in vivo lung-colonizing ability of tumor cells via a receptor, a cell surface glycoprotein of 78kD (gp78)-mediated signaling pathway. AMF induces gp78 internalization to intracellular tubulovesicles including lysosome and transport to the leading edge. The AMF-gp78 complex internalization from the cell surface is involved in control of cell motility during metastasis.