Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase

Fructose-1,6-bisphosphatase and inositol monophosphatase are found to share a similar secondary structure topology even though their sequences have very limited homology. Both enzymes have a layered alpha beta alpha beta alpha type structure and similar tertiary structures. All but one of the metal binding residues are conserved between these two enzymes and homologous proteins. The exception is Glu-280 in fructose-1,6-bisphosphatase to Asp-220 in inositol monophosphatase.