Related Experiment Videos
HLA-B8,DR3 phenotype and the antibody response against Epstein-Barr virus
C Caruso1, G Candore, A T Colucci
1Istituto di Patologia generale, Università di Palermo, Italy.
Immunological Investigations
|February 1, 1993
Abstract:
Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-B8,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-B8,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-B8,DR3 negative ones. These results further strengthen the suggestion that HLA-B8,DR3 positive subjects are low responders and that the depth of immune response depends on the fashion of antigenic challenge.