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Related Experiment Videos

Less painful alternatives for local anesthesia

G Lugo-Janer1, M Padial, J L Sánchez

  • 1Department of Dermatology, University of Puerto Rico School of Medicine, San Juan 00936-5067.

The Journal of Dermatologic Surgery and Oncology
|March 1, 1993
PubMed
Summary

Pain from local anesthetic infiltration can be reduced. A buffered saline solution with epinephrine was found to be less painful than standard lidocaine formulations, offering an effective alternative for superficial procedures.

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Area of Science:

  • Anesthesiology
  • Dermatology
  • Pain Management

Background:

  • Local anesthetic infiltration is often painful.
  • Acidity of anesthetic solutions is a suspected cause of infiltration pain.

Purpose of the Study:

  • To compare pain and anesthesia duration of different local anesthetic formulations.
  • Investigate the efficacy of buffered solutions for reducing infiltration pain.

Main Methods:

  • A three-phase study involving double-blind and open clinical trials.
  • Intradermal infiltration pain and anesthesia duration were assessed for various lidocaine and saline preparations.

Main Results:

  • Bacteriostatic saline with epinephrine (1:300,000) was significantly less painful than lidocaine with epinephrine and sodium bicarbonate.
  • The saline preparation proved effective for superficial surgical procedures.
  • pH values ranged from 4.2 to 7.4 across tested solutions.

Conclusions:

  • Pain from infiltration is not solely dependent on the pH of the anesthetic solution.
  • Buffered saline solutions offer a less painful alternative to traditional lidocaine formulations for certain procedures.

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